Recurrent Miscarriage, RCOG Guideline (June, 2023)
AAUN Obs and Gynae AAUN Obs and Gynae
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 Published On Jul 5, 2023

Recurrent miscarriage has been defined as three or more first trimester miscarriages. However, clinicians are encouraged to use their clinical knowledge to recommend extensive evaluation after two first trimester miscarriages, if there is a suspicion that the miscarriages are of pathological and not of sporadic nature. Women with recurrent miscarriage should be offered testing for acquired thrombophilia, particularly for lupus anticoagulant and anticardiolipin antibodies, prior to pregnancy. Women with second trimester miscarriage may be offered testing for Factor V Leiden, prothrombin gene mutation and protein S deficiency, ideally within a research context. Inherited thrombophilia’s have a weak association with recurrent miscarriage.
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 hormone replacement therapy

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