GDF11, one more molecule that seems to go into decline as we age. But boosting levels of this peptide could potentially reap huge regenerative and longevity benefits. The jury is still out on this one, but the early research shows huge promise.

In today’s video, we’ll explore Growth Differentiation Factor 11, better known as GDF11. We’ll talk about what it is, what it does, and its impact on aging and longevity. We’ll take a look at the many benefits that are attributed to GDF11, and the controversy surrounding those benefits…or lack thereof.

And finally, we’ll take a look at one citizen scientist who has conducted research on GDF11…on himself. And the data that he and a cohort of volunteers have collected on this molecule.
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CHAPTERS & TIMESTAMPS:
Intro: 00:00
What Is GDF11? 01:25
How Does GDF11 Impact Aging? 03:17
Aging Benefits of GDF11: 04:30
Contradictory Research on GDF11:
Steve Perry: 13:38
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Links to Steve Perry's sources:
Join Steve's study: https://gdf11rejuvenation.com/join-ou...
GDF11: https://www.buckylabs.com/gdf11/
Devices needed to monitor biomarkers: https://gdf11rejuvenation.com/daily-t...
Steve's White Paper (including dosing guidelines): https://docs.google.com/document/d/1s...
GDF11 spreadsheets in Google Drive: https://drive.google.com/drive/folder...
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Links To Studies In This Video:
Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice: https://www.nature.com/articles/s4159...

Loss of Growth Differentiation Factor 11 Shortens Telomere Length by Downregulating Telomerase Activity: https://www.ncbi.nlm.nih.gov/pmc/arti...

GDF11 modulates NGN3+ islet progenitor cell number and promotes β-cell differentiation in pancreas development: https://journals.biologists.com/dev/a...

Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction‐like phenotype in aged mice: https://onlinelibrary.wiley.com/doi/1...

Gdf11 gene transfer prevents high fat diet‑induced obesity and improves metabolic homeostasis in obese and STZ‑induced diabetic mice: https://translational-medicine.biomed...

GDF11 enhances therapeutic efficacy of mesenchymal stem cells for myocardial infarction via YME1L-mediated OPA1 processing: https://www.ncbi.nlm.nih.gov/pmc/arti...

GDF11 Protects against Endothelial Injury and Reduces Atherosclerotic Lesion Formation in Apolipoprotein E-Null Mice: https://www.ncbi.nlm.nih.gov/pmc/arti...

Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells: https://www.ncbi.nlm.nih.gov/pmc/arti...

Growth differentiation factor 11 (GDF11) has pronounced effects on skin biology: https://www.ncbi.nlm.nih.gov/pmc/arti...

Anti-Aging Effects of GDF11 on Skin: https://www.ncbi.nlm.nih.gov/pmc/arti...

Administration of rGDF11 retards the aging process in male mice via action of anti-oxidant system: https://link.springer.com/article/10....

Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle: https://www.ncbi.nlm.nih.gov/pmc/arti...

Growth Differentiation Factor 11 is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy: https://www.ncbi.nlm.nih.gov/pmc/arti...

GDF11 restrains tumor growth by promoting apoptosis in pancreatic cancer: https://www.ncbi.nlm.nih.gov/pmc/arti...

GDF11 Implications in Cancer Biology and Metabolism. Facts and Controversies: https://www.ncbi.nlm.nih.gov/pmc/arti...

GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation: https://www.ncbi.nlm.nih.gov/pmc/arti...

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