Our gastrointestinal tract is important for our nutrient absorption and waste excretion and is home to most of our microbiota. Diseases affecting the gut, such as Crohn’s disease, lead to serious signs and complications. The biggest concern is knowledge gaps in why Crohn’s disease develops and treatment options. For this video, we got in touch with Dr. Sabah Haq,
a member of Dr. Waliul Khan’s lab that investigated the “Disruption of autophagy by increased serotonin alters gut microbiota and enhances susceptibility to experimental colitis and Crohn’s disease.” We also touch on another one of Dr. Khan’s papers, the impacts of Allura Red, an artificially added food colour in different snacks and treats, on the intestine
and the development of IBD (inflammatory bowel disease) and IBS (irritable bowel syndrome).

This video is for general and education purposes only. Please consult your healthcare provider for information about your health.

This video was made by Mandy Liangm Aveena Sriharan and Alisha Sarwar in collaboration with the Demystifying Medicine McMaster Program.

Copyright McMaster Univerisity 2024.

#IBD #IBS #BowelDisease #Crohn'sDisease #Serotonin #Autophagy #AlluraRed

References:
Haq, S., Wang, H., Grondin, J., Banskota, S., Marshall, J. K., Khan, I. I., Chauhan, U., Cote, F., Kwon, Y. H., Philpott, D., Brumell, J. H., Surette, M., Steinberg, G. R., & Khan, W. I. (2021). Disruption of autophagy by increased 5-HT alters gut microbiota and enhances susceptibility to experimental colitis and crohn’s disease. Science Advances, 7(45). https://doi.org/10.1126/sciadv.abi6442

Kwon, Y. H., Banskota, S., Wang, H., Rossi, L., Grondin, J. A., Syed, S. A., Yousefi, Y., Schertzer, J. D., Morrison, K. M., Wade, M. G., Holloway, A. C., Surette, M. G., Steinberg, G. R., & Khan, W. I. (2022). Chronic exposure to synthetic food colorant Allura Red AC promotes susceptibility to experimental colitis via intestinal serotonin in mice. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-35...

Roda, G., Chien Ng, S., Kotze, P. G., Argollo, M., Panaccione, R., Spinelli, A., Kaser, A., Peyrin-Biroulet, L., & Danese, S. (2020). Crohn’s disease. Nature Reviews Disease Primers, 6(1). https://doi.org/10.1038/s41572-020-01...

Trivedi, I., Reddy, S., Rosh, J., & Keefer, L. (2016). Patient understanding of “Flare” and “Remission”. Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates, 42(4), 375–385.
https://doi.org/10.1097/01.mib.000048...

Ye, Y., Pang, Z., Chen, W., Ju, S., & Zhou, C. (2015). The epidemiology and risk factors of inflammatory bowel disease. International Journal of Clinical and Experimental Medicine, 8(12), 22529–22542.