In this video, double board certified neurologist Neurogal MD discusses the human clinical evidence for Ashwagandha and also touches on safety and side effects of Ashwagandha.

Disclaimer:
This video is provided as an informational resource only, and does not create a patient-physician relationship. This video does not constitute medical advice and is not an alternative to medical advice from your physician. Please speak with your physician before starting any supplement.
This video does NOT represent a recommendation for these specific products.The brand info in this video is up to date as of May, 2022 (any data beyond this date is not reflected in this video).

REFERENCES:
Ashwagandha on Stress and Anxiety:
Cooley K, Szczurko O, Perri D, Mills EJ, Bernhardt B, Zhou Q, Seely D. Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974. PLoS One. 2009 Aug 31;4(8)
Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019 Sep;98(37)
Andrade, C et al. “A double-blind, placebo-controlled evaluation of the anxiolytic efficacy of an ethanolic extract of withania somnifera.” Indian journal of psychiatry vol. 42,3 (2000): 295-301
Choudhary D, et al. Body weight management in adults under chronic stress through treatment with ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. J Evid Based Complementary Altern Med. 2017 Jan;22(1):96-106
Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study. Cureus. 2019 Sep 28;11(9)
Salve, J. et al. Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Cureus 2019
Chengappa KNR, et al. Adjunctive use of a standardized extract of withania somnifera (ashwagandha) to treat symptom exacerbation in schizophrenia: a randomized, double-blind, placebo-controlled study. J Clin Psychiatry 2018
Gannon JM, et al. Effects of a standard- ized extract of Withania somnifera (Ashwagandha) on depression and anxiety symptoms in persons with schizophrenia participating in a randomized, placebo-controlled clinical trial. Ann Clin Psychiatry 2019; 31(2): 123-9.
Chandrasekhar K, et al. A prospective, random- ized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med 2012; 34(3): 255-62
Auddy B, et al. A standardized withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: a double-blind, randomized, placebo-controlled study. Journal of the American Neutraceu- tical Association 2008; 11(1): 50-6.
Khyati S, et al. A randomized double blind placebo controlled study of ashwagandha on generalized anxiety disorder. International Ayurvedic Medical Journal 2013; 1(5): 1-7.
Fuladi S, et al. Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial. Curr Clin Pharmacol 2020.
Cooley K, et al. Naturopathic care for anxiety: a randomized controlled trial
Auddy B, et al. A standardized withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: a double-blind, randomized, placebo-controlled study. Journal of the American Neutraceutical Association 2008; 11(1)
Lopresti AL, et al. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019 Sep;98(37)

Insomnia/Sleep
Cheah KL, et al. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. 2021;16(9)
Deshpande A, et al. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Sleep Med. 2020;72:28-36.
Langade D, et al. Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study. J Ethnopharmacol. 2021 Jan 10

Memory/Cognition:
Choudhary D, et al. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions. J Diet Suppl. 2017 Nov 2;14(6)
Remenapp A, et al. Efficacy of Withania somnifera supplementation on adult's cognition and mood. J Ayurveda Integr Med. 2021 Nov 25;13