If you’re a long-time listener of *The Proof*, you’ll know that I have a deep passion for better understanding heart disease and communicating this knowledge alongside the world’s leading scientists. This personal interest is one that I’m sure many listeners will share; almost everyone has either personally struggled with cardiovascular health or knows someone who has. In this three-part series with Dr Thomas Dayspring, we undertake an extended education journey on cardiovascular disease and blood lipids.

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Episode #251 forms Part One of this series. In this conversation, Dr Dayspring provides the foundational, technical knowledge needed to understand blood lipids, taking a deep dive into how our body absorbs lipids (fats and sterols) and transports them throughout the body. All in all, we examine what the lipid transport system is, the key parts of the system, and what happens when it goes wrong.

Dr Thomas Dayspring is a Fellow of both the American College of Physicians and the National Lipid Association and is certified in internal medicine and clinical lipidology. He is currently a virtual cardiovascular educational research assistant and clinical lipidology at a prestigious national practice, and has given over 4000 domestic and international lectures among a suite of other career achievements. Dr Dayspring is a true expert in lipidology, and continuously helps wider audiences make sense of this complex topic.

In this introductory episode, listeners will gain a deeper appreciation for what cholesterol and triglycerides are, how they are absorbed in the small intestine, and how they are transported through plasma (circulation). Dr Dayspring clearly outlines the two primary places where lipoproteins are produced – the small intestine and liver – and the function of the major classes of lipoproteins (chylomicrons, VLDLs, IDLs, LDLs, and HDLs).

We consider risk factors for atherosclerosis, discussing what goes wrong within the lipid transportation system that causes cholesterol to be deposited into the artery wall in a process called atherogenesis. We also address misconceptions about cardiovascular disease and the endothelium that are commonly perpetuated online, genetic influence, dietary cholesterol, and much, much more.

Knowledge is power, and understanding your body is the most powerful tool you can have for taking control of your health. I hope you find value in Part One of this masterclass with Dr Dayspring, and appreciate his attention to detail, patience, and obvious passion. I know Dr Dayspring’s work has helped me make sense of this complex system, and the tips imbedded throughout this episode will help you better understand your own body. Stay tuned for Part Two and Part Three of this series, where we will examine how to assess cardiovascular disease risk, prevent it, and treat it.

00:00 - Intro
05:12 - Turning a family heartache into a mission 
14:52 - Atherosclerosis and the role of lipids
28:01 - Lipoproteins & cholesterol transport and recycling
54:00 - Cholesterol's role in lipoproteins
58:38 - Is ApoB a more accurate marker of cardiovascular risk?
1:07:10 - Endothelial transcytosis of lipoproteins 
1:16:42 - LDL aggregation
1:23:35 - LDL particle retention and inflammation
1:29:15 - Difference between veins and arteries
1:30:42 - Atherosclerosis and genetics
1:44:21 - High-fat diets and cholesterol 
1:48:34 - Fiber and cholesterol absorption 
1:58:08 - Outro

Connect with Dr Thomas Dayspring on Twitter at   / drlipid  .

We’ve also got a Summary PDF being created with the key learnings from each part of the series. To receive a copy of this simply submit your email at https://theproof.com/lipid-series/.

And we are working on transcripts for these episodes too (release date TBC).

If you have any additional questions you would like answered in the future, let me know in the comments.

The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit http://theproof.com/friends.

Enjoy, friends.

Simon

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