Thiamine (Vitamin B1) is a universal "anti-stress" molecule, and quite unique as a B vitamin

Remarkably, it serves as one of the FIRST and primary defenses against stress (of any kind) in plants, bacteria, fungi, and throughout the animal kingdom. This should tell you something.

In nature: Thiamine = stress resistance

When a human cell is hypoxic (deficient in oxygen), it rapidly uptakes thiamine. In fact, low thiamine and low oxygen evoke very similar (if not equivalent) effects on cell metabolism. They are almost synonymous.
In fact, by giving animals or isolated cells very high amounts of thiamine BEFORE exposure to an injury, an infection, or a toxin, it can largely protect the cell from injury (and in some cases, reverse the injury).

When a plant cell senses danger, it rapidly uptakes thiamine also. Genes are transcribed which upregulate the activity of thiamine-dependent enzymes. Thiamine is used as an activator to promote resistance against many forms of disease.

Bacteria accumulate different forms of thiamine, and increase the amount that they make in anticipation of danger. Thiamine is used as a danger signal, or "alarmone".

I am working on a new video/lecture, which looks at how thiamine is used by living organisms as a "stress signalling molecule" (including in humans), and is rapidly used up as a means adapting to increased demands placed on the cell.

Interestingly, many of these functions appear independent of thiamine's role in energy metabolism. Non-coenzyme/signalling/genetic effects of thiamine appear to play a significant role in mobilizing protective responses.

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DISCLAIMER: Elliot is not a medical professional and the information in this video is provided for general informational and educational purposes only and is not a substitute for professional advice. Always consult with your primary healthcare provider for medical advice.

#thiamine #vitaminb1 #stress #mitochondria