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The R-Files episode 1:    • An introduction to the study of RAPAM...  
The R-Files episode 2:    • Off-Label Rapamycin Experiences & Dos...  
The R-Files episode 3:    • Rapamycin's possible SIDE EFFECTS & B...  

The R-Files is a series of episodes about rapamycin, a naturally occurring compound originally discovered in soil samples from Easter Island, also known as Rapa Nui (hence the drug's name). Rapamycin belongs to a class of drugs called macrolides and has potent immunosuppressive and anti-proliferative effects. The drug has garnered attention for its potential anti-aging properties and has attracted research interest for its ability to extend lifespan and delay age-related diseases in various model organisms, including yeast and mice.

In the fourth episode of the R-Files, Matt discusses research demonstrating that rapamycin rejuvenates the aged mouse immune system to respond to a flu vaccine as if it were in a youthful state. He also discusses papers suggesting that rapamycin may have similar effects on human immune systems.

0:00 Trailer
0:41 Introduction
1:25 A big year for rapamycin: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
2:38 mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells
8:50 The immune challenge experiment
18:20 Unanswered questions
19:20 The lifespan experiment
25:26 Caveats
26:46 Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
27:48 Translation to humans
28:27 TORC1 inhibition enhances immune function and reduces infections in the elderly
34:52 mTOR inhibition improves immune function in the elderly
38:44 Takeaways

Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa

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https://www.optispan.life/

Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

On this channel I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these videos helpful!