Presented By: Lydia L. Sohn, PhD

Speaker Biography: Lydia L. Sohn received her A.B. (Chemistry and Physics, 1988), M.S. (Physics, 1990), and Ph.D. (Physics, 1992) from Harvard University. She was an NSF/NATO postdoctoral fellow at Delft University of Technology (1992-1993) and a postdoctoral fellow at AT&T Bell Laboratories (1993-1995) prior to joining the Physics faculty at Princeton University in 1995. Since 2003, Sohn has been a professor in the Mechanical Engineering Department at UC Berkeley, where she is now holds the Almy C. Maynard & Agnes Offield Maynard Chair in Mechanical Engineering. Sohn is a Core Member of the UCSF-UC Berkeley Joint-Graduate Group in Bioengineering. Her work focuses on developing and employing label-free, quantitative techniques to screen and identify single cells and extracellular vesicles for biomedical-research and clinical-diagnostic applications.

Webinar: Node-Pore-Sensing: A Versatile Method to Phenotype Cells

Webinar Abstract: We have developed an electronic method to screen cells for their phenotypic profile, which we call Node-Pore Sensing (NPS). NPS involves using a four-terminal measurement to measure the modulated current pulse caused by a cell transiting a microfluidic channel that has been segmented by a series of inserted nodes. By simply inserting between two nodes a straight “contraction” channel through which cells can squeeze, we can simultaneously measure a cell’s size, resistance to deformation, transverse deformation, and ability to recover from deformation. I will describe how we have used “mechano-NPS” to distinguish sublineages of primary human mammary epithelial cells and the chronological age groups (i.e. “young” vs. “old”) of women from which these cells were derived—all based on the mechanical properties of the cells measured. In addition to mechanophenotyping cells, I will show how we have performed label-free, immunophenotyping of cells using NPS.

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