In enzyme kinetics, Michaelis–Menten equation is a mathematical equation that relates velocity of enzyme V0, maximum velocity Vmax and Km. It explains both, the first order kinetics and zero order kinetics of typical graph of enzymatic reaction. Michaelis Menten equation starts with assumption that, enzyme, substrate and ES complex are under equilibrium. This assumption is also known as Equilibrium assumption. On the other hand Briggs Haldane assumed that the concentration of ES complex remains constant through out enzymatic reaction. This assumption is also known as pseudo-steady-state-hypothesis. Both Michaelis Menten and Briggs Haldane assumptions can be used for the derivation of equation.