The Mercedes-AMG GLC 63 S Coupé proven AMG 4.0-litre V8 biturbo engine puts out 375 kW (510 hp) with a max. torque of 700 Nm. Acceleration from zero to 100 km/h is completed in just 3.8 seconds. The top speed is 250 km/h (electronically limited).

This 4.0-litre eight-cylinder biturbo engine is already used in numerous AMG Performance vehicles. It is also installed in the AMG GT sports car with dry sump lubrication. A characteristic feature is that the two turbochargers are positioned not on the outside of the cylinder banks, but inside the cylinder "V". The main advantages of this design are the compact engine construction, optimal response and low exhaust gas emissions. One mechanic assembles each engine in the engine shop in Affalterbach according to the "one man – one engine" principle.

The new GLC 63 S 4MATIC+ coupe features the AMG SPEEDSHIFT MCT 9-speed transmission, which made its debut in the Mercedes-AMG E 63 4MATIC+. The driver benefits from extremely short shift/response times. Fast multiple downshifts and the double-declutching function make for a highly emotive gearshift experience. A start-off wet clutch replaces the torque converter. This saves weight and optimises the response to the driver's accelerator pedal input, particularly on acceleration and during load changes.