Vitamin B9--Folate vs Folic Acid

Folate is the natural form found in green leafy vegetables, yeast, avocados, fish and organ meats.
**several glutamate residues and in the reduced form.

Folic Acid-synthetic, monoglutamate, fully oxidized, more stable
**greater bioavailability by 1.7 than Folate
Example: 60 mcg of folate-----60 mcg DFE(dietary folate equivalent)
60 mcg of folic acid---102 mcg DFE(dietary folate equivalent)

However,
Folate is converted to the active 5-Methyltetrahydrofolate in the GI.
Folic Acid is converted in the GI, Liver and other tissues. Which slows the process which can create a build up of folic acid which is associated with increase CA risk(not conclusive and more studies are needed)

Causes of deficiency: increased alcohol use, low dietary intake, smoking, pregnancy, CA, inflammation, IBD

Symptoms: increase homocysteine, increase risk of CA, increase MI/CAD, infertility, migraines, depression, decrease neurotransmitters, detoxification issues, anemia

Lab: Homocysteine, MCV (megaloblastic anemia), serum folate/folic acid

Genetic testing: MTHFR (C677T, A1298C)

Supplements: methylfolate, L-5 Methyltetrahydrofolate
Cofactors for methylation: Vit C, E, riboflavin, P5P, B12(methylcobolamin), magnesium, choline, trimethylglycine, MSM

https://lpi.oregonstate.edu/mic/vitam...
https://www.ncbi.nlm.nih.gov/pmc/arti...
https://www.sciencedirect.com/science...
https://journals.sagepub.com/doi/10.1...
https://www.frontiersin.org/articles/...
https://www.ncbi.nlm.nih.gov/pmc/arti...
https://www.nature.com/articles/ejcn2...
https://pubmed.ncbi.nlm.nih.gov/17617...
https://pubmed.ncbi.nlm.nih.gov/30341...

Vitamin B6-   • Vitamin B6. The Forgotten B Vitamin  
B12 and autoimmunity-   • Autoimmunity causing B12 Deficiency  
B12-Cobalamin-   • B12----Cobalamin🥩🦪  
B1 Thiamin-   • Vitamin B1-Thiamin(e) Deficiency-----...  
Homocysteine-   • HOMOCYSTEINE the Forgotten Lab Marker...  

Dr. Jin Sung is a Chiropractic Physician who specializes in the management of complex chronic conditions in Massachusetts, 30 minutes north of Boston. He utilizes natural and alternative therapies to help manage complex cases such as Hashimoto's, autoimmune conditions, IBS, SIBO, chronic fatigue, brain fog, early Alzheimer's, etc.

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The content of this video is for educational purposes only and does not constitute medical advise. Please consult with your physician before embarking on any dietary changes or taking any nutritional supplements.