Tighten goes on a rampage, and kidnaps Roxanne when she tries to get through to him. On a televised message, Tighten holds Roxanne hostage and demands that Megamind fight him. With Minion's help, Megamind escapes prison, where he goes to confront Tighten, using holographic disguises to make himself appear as Metro Man, and Minion as Megamind, to frighten Tighten away and rescue Roxanne. However, Megamind's speech patterns give him away, and Tighten attacks Megamind, throwing him into the stratosphere. Dehydrating himself into a cube and landing safely in a fountain, Megamind rehydrates next to Tighten and extracts the DNA from him, removing his powers.

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