Muscle loss, also known as sarcopenia, is a natural part of aging that occurs due to various factors, such as reduced physical activity, hormonal changes, and protein deficiency. Muscle loss can lead to weakness, mobility problems, falls, fractures, and increased risk of chronic diseases.

There are also various genetic diseases that result in muscle loss and reduced function and hence much research has been conducted to find therapeutic solutions focusing on myostatin and follistatin. We'll take a look at a mouse study that saw longevity benefits following follistatin gene therapy and some clinical trials in development.

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TIMESTAMPS
Intro - 00:00
Myostatin - 00:55
Follistatin - 02:11

References:
McPherron, A., Lawler, A. & Lee, SJ. Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member. Nature **387**, 83–90 (1997). https://doi-org.ezp.lib.cam.ac.uk/10....
New intranasal and injectable gene therapy for healthy life extension - https://doi.org/10.1073/pnas.2121499119
Follistatin-induced muscle hypertrophy in aged mice improves neuromuscular junction innervation and function - https://doi.org/10.1016/j.neurobiolag...
Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates - https://doi.org/10.1126/scitranslmed....

Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.