B12 deficiency is potentially dangerous and can cause neurological diseases such as peripheral neuropathy, subacute combined degeneration of the spinal cord, optic neuropathy, and dementia. This video reviews absorption of B12, common causes of deficiency, laboratory testing, and abnormal imaging findings.

Selected Sources:

Neurological disorders in vitamin B12 deficiency: https://pubmed.ncbi.nlm.nih.gov/31094...
Clinical, nerve conduction and nerve biopsy study in vitamin B12 deficiency neurological syndrome with a short-term follow-up: https://pubmed.ncbi.nlm.nih.gov/24256...
Coma and Axonal Degeneration in Vitamin B12 Deficiency: https://jamanetwork.com/journals/jama...
Clinical and Brain Imaging Findings in a Child with Vitamin B12 Deficiency: https://www.mdpi.com/2036-7503/13/4/69
Vitamin B12 Deficiency and Impact on MRI Morphometrics: Association Between Cognitive Impairment and Neuroimaging Findings: https://link.springer.com/referencewo...
Vitamin B12 deficiency manifesting as reversible leukoencephalopathy and ataxia: https://www.neurology-asia.org/articl...
Why it's not a good idea to keep vitamin B12 a secret: case report of thrombosis in the brain and hydrocephalus in a vegan in Sri Lanka: https://www.christiankoeder.com/2020/...
Vitamin B12 Deficiency Causes Chiasmal Lesion: https://www.reviewofoptometry.com/art...
Pseudo-Foster Kennedy Syndrome as a Rare Presentation of Vitamin B12 Deficiency: https://www.semanticscholar.org/paper...



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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.