This case is based on publication in literature by Harrison R, Warburton V, Lux A, Atan D. Ann Intern Med. 2019 Sep 3. Link below. Non-clinical elements (e.g. initials, story details, etc) are adapted. Peer Review: Dr. Nikhil Parelkar.

I originally had another case for video of a vitamin b12 deficiency I saw as a student about a girl on an overly strict diet. I didn't release it because the details were more difficult than I would like for a video. The clinical principles and science of that case and this one are the same.

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Medicine (Playlist) ►    • Medicine  

Toxicology (Playlist) ►    • Toxicology  

A Boy Ate 150 Gummy Vitamins For Breakfast. This Is What Happened To His Bones. ►    • A Boy Ate 150 Gummy Vitamins For Brea...  

A Mom Drank 3 Gallons Water In 2 Hours. This is What Happened to Her Brain. ►    • A Mom Drank 3 Gallons Water In 2 Hour...  

A Grandma Ate Cookie Dough For Lunch Every Week. This Is What Happened To Her Bones. ►    • A Grandma Ate Cookie Dough For Lunch ...  

These cases are patients who I, or my colleagues have seen. They are de-identified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet, see your own physician in person for that.

References:

MRI Images courtesy Dr Bruno Di Munzio. Radiopaedia.org rID:41113

[0] Harrison R, Warburton V, Lux A, Atan D. Ann Intern Med. 2019 Sep 3. https://www.ncbi.nlm.nih.gov/pubmed/3...

[1] Chanarin I, et. al. A History of Pernicious Anaemia. Br J Haematol. 2000 Nov;111(2):407-15. https://www.ncbi.nlm.nih.gov/pubmed/1...

[2] Scott JM, et. al. The Discovery of Vitamin B12. Ann Nutr Metab 2012;61:239–245. https://www.ncbi.nlm.nih.gov/pubmed/2...

[3] Scherer K. Neurologic Manifestation of Vitamin B12 Deficiency. N Engl J Med 2003; 348:2208.

[4] Ashkenazi, S. et. al Vitamin B12 deficiency due to a strictly vegetarian diet in adolescence.. Clin Pediatr (Phila). 1987 Dec;26(12):662-3. https://www.ncbi.nlm.nih.gov/pubmed/3...

[5] Li, K. And McKay G. Ischemic Retinopathy Caused By Severe Megaloblastic Anemia. N Engl J Med 2000; 342:860. https://www.ncbi.nlm.nih.gov/pubmed/1...

[6] Cuba Neuropathy Field Investigation Team. Epidemic optic neuropathy in Cuba--clinical characterization and risk factors. N Engl J Med. 1995 Nov 2;333(18):1176-82. https://www.ncbi.nlm.nih.gov/7565972

[7] Sadun AA. Metabolic optic neuropathies. Semin Ophthalmol. 2002 Mar;17(1):29-32. https://www.ncbi.nlm.nih.gov/15513453

[8] Bunn HF. Vitamin B12 and Pernicious Anemia- The Dawn Of Molecular Medicine. N Engl J Med 2014; 370:773-776. https://www.ncbi.nlm.nih.gov/24552327

[9] Hodgkin DC, Kamper J, Mackay M, Pick- worth J, Trueblood KN, White JG: Structure of vitamin B12. Nature 1956;178:64–66.

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