Straight from the box, I had some pretty serious issues after my initial setup. I could not get the first layer properly calibrated, and the fancy prusament PLA would not stick to the bed. I also had some assembly issues that caused some concern. Luckily, these were all pretty well-documented issues that were quick to fix!

Credits / Links:
Bobstro from the prusa forums runs an amazing blog/wiki resource thing and he solved my calibration and adhesion issues with these following links:
http://projects.ttlexceeded.com/3dpri...
http://projects.ttlexceeded.com/3dpri...

As for the mechanical issues:
Detailed documentation lives on the Prusa Help Site:
https://help.prusa3d.com/article/e6ty...
Though this video is what clued me in initially:
   • Prusa mini hotend / underextrusion fix  

The Cali Cat! by Dezign https://www.thingiverse.com/thing:154...