A NHTSA Full-Overlap Frontal Crash Test at 35 Mph (56 Km/h). Driver is a 50th Percentile Male, and the passenger is a 5th Percentile Female. Earned Four Stars for the driver and Five Stars for the passenger, earning Five Stars overall.

NHTSA Frontal Crash Test of the 2021 Mercedes-Benz E 350 Sedan.
Rating based on 2011+ criteria.

Rating also applies to the:
2021+ E 300, E 450, AMG E 53, AMG E 63 Sedan, Wagon, and Hybrid variants.

Driver - Passenger
**** - ***** (Five Stars Overall)
HIC 190 - 204
Chest G's 42 - 44
Femur Load (L/R) 1722/2139 - 1145/1370