Sara Pezzini, beautiful homicide detective who came into possession of mystical sentient gauntlet/bracelet called Witchblade whose powers always emerge when danger threatens when dealing with supernatural enemies.

#20 Demonic serial killer from Witchblade-Demon and Witchblade-Demon Reborn.
#19 A telepath from "Level 42" who led the superhumans to attack Sara.
#18 A power-hungry man who played his own games by pitting people against each other. Linked to "Microwave Murders" as companion #11.
#17 Powerful witch from 17th century who fired Sara to collect some artifacts and they quickly got into a fight.
#16 Woman with magical skin, she can mind control people with her tattoos.
#15 Ancient sea goddess defeated by Witchblade and Angelus in ancient Babylon. Catburglar stole her crown from the museum and she became the new version to take revenge on her enemies.
#14 Motorcycle gang whose members are sexy witches.
#13 A time traveling supervillain who needed Witchblades from different eras to control timelines.
#12 Demonic entity brought to earth by church secret society. Sara's police partner Jake died when he took over his body.
#11 Lover of #1 who has a piece of Witchblade inside her. To maintain her strength she must absorb life force from young maidens, so called ""Microwave Murderer".
#10 Sara's false guide and Curator's brother. He turned Sara to dark side in "the War of the Witchblades".
#9 "Tiger of Death", a skilled assassin and explosives expert from Hong Kong with no morals. Served many employers like #1.
#8 Son of #1 and as bad as his father. He has inherited obsession with Witchblade.
#7 A hipster -style woman who is more dangerous than it looks, Sara sworn an enemy who wants to destroy and corrupt everything that is good.
#6 Traditional supervillain who like to burn things and can control fire.
#5 Beautiful gynoid assassin who killed Sara's sister and kidnapped her child for #4.
#4 Curator was an old Asian man and Sara's good guide to the world of artifacts until he went full Thanos mode to destroy and reshape whole universe by bringing all 13 artifacts together.
#3 Sara's arch-villainess, Jekyll&Hyde/Two-Face style dual-minded woman who does very bad things after doing some good things and she's obsessed with Witchblade.
#2 Charming mercenary and assassin who served #1 and one of the main characters in the series. He and Sara have love/hate relationship, Sometimes they are allies but usually enemies.
#1 Sara's archnemesis. Rich powerful man from Medieval times when he drank from Graal and became immortal. He is naturally obsessed with Witchblade and its powers and the main reason that it ended up with Sara.