Temelimab (GNbAC1) is a drug being developed for multiple sclerosis which targets the envelope protein of human endogenous retrovirus W.

Please watch this video for a background on why people believe HERV-W may be part of the cause of MS:    • Does HERV-W Cause Multiple Sclerosis?...  

This video reviews human endogenous retroviruses, temelimab, and the results from 3 clinical trials.

Selected Sources:

Presentation on Temelimab by GenNeuro: https://geneuro.com/data/documents/GN... phase IIa randomised clinical study of GNbAC1, a humanised monoclonal antibody against the envelope protein of multiple sclerosis-associated endogenous retrovirus in multiple sclerosis patients: https://pubmed.ncbi.nlm.nih.gov/25392...
The Envelope Protein of a Human Endogenous Retrovirus-W Family Activates Innate Immunity through CD14/TLR4 and Promotes Th1-Like Responses: https://journals.aai.org/jimmunol/art...
Update on CHANGE-MS: Clinical Trial Results for GNbAC1: https://practicalneurology.com/articl...
Efficacy and safety of temelimab in multiple sclerosis: Results of a randomized phase 2b and extension study: https://pubmed.ncbi.nlm.nih.gov/34240...


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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.