So the question is: Do you spend $30 or $125 on a vertical ergonomic mouse? Does it matter? Will the cheaper one be better or worse? I’ve tested 12 of the most popular vertical ergonomic mice and I’ve got 5 that are worth getting.

Here are the Top 5 along with the Amazon affiliate links:

Logitech MX Vertical Advanced - https://mreh.ca/3TxdjZG
Logitech Lift Vertical - https://mreh.ca/3vq6cds
Kensing Vertical Ergonomic Mouse - https://mreh.ca/4arQ7CK
ProtoArc EM11 Wireless Ergonomic Mouse - https://mreh.ca/49nShTj
DELUX Rechargeable Wireless Mouse* - https://mreh.ca/3TuCtbd OR Perixx PERIMICE-819B Bluetooth Portable Vertical Mouse - https://mreh.ca/3TmDDp2
*I wasn’t able to find this mouse on Amazon.com

For our ranking, I weigh the scores across a multitude of different criteria (15 for vertical ergonomic mice) and wrist pain relief accounts for 35% of the score. If all you care about is wrist relief consider getting the Evoluent Vertical Mouse D. The hand angle is almost 90 degrees so there is no twisting of your forearm at all. Be warned though, it’s the most expensive mouse I’ve tested.

See how much the Evoluent Vertical Mouse D is on Amazon:

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#1 Logitech MX Vertical Advanced - https://mreh.ca/3TxdjZG

-Top choice for its synergy of build and software.
-Boasts a 57-degree angle and a soft rubber grip suitable for larger hands.
-Customizable buttons and scroll wheel via Logi+ on Mac/Windows.
-Charges internally and connects to three devices, missing dongle storage.
-Priced higher but fails on glass surfaces.
-Thumb button customization on Mac with Logi+ is exceptional.
-Solid build, easy handling, and multi-device workflow efficiency.

#2 Logitech Lift Vertical Ergonomic Mouse - https://mreh.ca/3vq6cds
-A compact pick, unexpectedly effective, ideal for travel.
-Excels with 57-degree lift, textured grip, and versatile Logi+ Options for Mac.
-Includes 4 silent-click buttons, speed-adjusting scroll wheel, and AA battery life with dongle storage.
-Compatible with most surfaces, offering a wide DPI range.
-At $75, it balances cost with superior features.

#3 Kensington Vertical Ergonomic Mouse/Pro Fit Ergo - https://mreh.ca/4arQ7CK
-Standout for its value, surpassing the Pro version in function and cost.
-A more familiar 47-degree angle, with supportive C-grip and pinky rest.
-Standard model offers up to 2400 DPI, with a soft matte finish.
-Kensington software customizes the Pro’s buttons but skips the standard.
-Both powered by AA batteries, non-silent clicks, and no glass surface functionality.
-Questions the Pro's extra cost given the standard's comparable features.

#4 ProtoArc EM11 Ergonomic Mouse - https://mreh.ca/49nShTj

-Notable "oven mitt" shape with customizable LED flair.
-Three DPI levels, silent main clicks, textured grip.
-Long battery life, multi-connection sans USB-C.
-Fixed scroll speed and potential wrist repositioning awkwardness.
-Mac thumb buttons need third-party software.
-Visually striking with practical multi-device use.

#5 Delux Rechargeable Wireless Mouse - https://mreh.ca/3TuCtbd

-57-degree hand position, smooth body with fixed LED colors.
-Silent clicks, four buttons, with distinct thumb placement.
-Limited internal battery capacity, easy dongle access.
-Lacks on glass surfaces, with a consistent scroll speed.
-LED aesthetic adds vibrancy to the white variant.


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