Chilli Peppers are not only delicious, but healthy for you too! Learn about some incredible health benefits of the Chilli (Capsicum). Citations listed below.

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0:00:00 Intro
0:00:20 The Basics: Vitamins and Minerals, and Capsaicin
0:01:50 Cardiovascular/Heart Health
0:02:34 IBS/Gastrointestinal Health
0:03:44 Thermoregulatory Effects
0:04:49 Analgesic: Pain Relief
0:06:11 Incontinence
0:06:55 Alzheimer's Disease/Cognitive Degradation
0:07:58 Diabetes and Obesity
0:08:28 Cancer

TRPV1:
· Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. "The capsaicin receptor: a heat-activated ion channel in the pain pathway." Nature 389.6653 (1997): 816-824.

Cardiovascular/Heart Health
· American Chemical Society (ACS). "Hot pepper compound could help hearts." ScienceDaily. ScienceDaily, 27 March 2012.
· Segawa, Yukiko et al. “Dietary capsaicin-mediated attenuation of hypertension in a rat model of renovascular hypertension.” Clinical and experimental hypertension (New York, N.Y. : 1993) vol. 42,4 (2020): 352-359. doi:10.1080/10641963.2019.1665676

IBS/Gastrointestinal Health
· Perveen I, Hasan M, Masud MA, Bhuiyan MM, Rahman MM. Irritable bowel syndrome in a Bangladeshi urban community: prevalence and health care seeking pattern. Saudi J Gastreonterol 2009;15:239-243
· Gwee KA, Lu CL, Ghoshal UC. Epidemiology of irritable bowel syndrome in Asia: something old, something new, something borrowed. J Gastroenterol Hepatol 2009;24:1601-1607
· Holzer P. TRPV1: a new target for treatment of visceral pain in IBS? Gut 2008;57:882-884.
· Herrera-Lopez JA, Mejia-Rivas MA, Vargas-Vorackova F, Valdovinos- Diaz MA. Capsaicin induction of esophageal symptoms in different phenotypes of gastroesophageal reflux disease. Rev Gastroenterol Mex 2010;75:396-404.

Thermoregulatory Effects
· Basith S, Cui M, Hong S, Choi S. Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases. Molecules. 2016 Jul 23;21(8):966. doi: 10.3390/molecules21080966. PMID: 27455231; PMCID: PMC6272969
· Hogyes, A., Beitrage zur physiologischen Wirkung der Bestandteile des Capsicum annum, Arch. Exp. Path. Pharmak., 9, 117, 1878.
· Issekutz (pronounce: Issgutz), B., Lichtneckert, I., and Winter, M., Effect of histamine, capsaicin, and procanine on heatregulation, Arch. Int. Pharmacodyn, 83, 3 19, 1950a.
· Issekutz, B., Lichtneckert, I., and Nagy, H., Effect of capsaicin and histamine on heat regulation, Arch. Int. pharmacodyn.. 81, 35, 1950b

Analgesic: Pain Relief
· Conway, Stuart J. "TRPing the switch on pain: an introduction to the chemistry and biology of capsaicin and TRPV1." Chemical Society Reviews 37.8 (2008): 1530-1545.
· Fusco, B. M., G. Barzoi, and F. Agro. "Repeated intranasal capsaicin applications to treat chronic migraine." British journal of anaesthesia 90.6 (2003): 812-812.

Incontinence
· Daly D, Rong W, Chess-Williams R, Chapple C, Grundy D. Bladder afferent sensitivity in wild-type and TRPV1 knockout mice. J Physiol. 2007 Sep 1;583(Pt 2):663-74. doi: 10.1113/jphysiol.2007.139147. Epub 2007 Jul 12. PMID: 17627983; PMCID: PMC2277033.
· Fraser MO, Lavelle JP, Sacks MS, Chancellor MB. The future of bladder control-intravesical drug delivery, a pinch of pepper, and gene therapy. Rev Urol. 2002 Winter;4(1):1-11. PMID: 16985646; PMCID: PMC1475956.

Alzheimer's Disease/Cognitive Degradation
· Wang J, Sun BL, Xiang Y, et al. Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer's disease-type pathology and cognitive deficits in APP/PS1 mice. Transl Psychiatry. 2020;10(1):230. Published 2020 Jul 13. doi:10.1038/s41398-020-00918-y
· Liu, Cheng-Hui, et al. "The associations between a capsaicin-rich diet and blood amyloid-β levels and cognitive function." Journal of Alzheimer's Disease 52.3 (2016): 1081-1088.

Diabetes and Obesity
· Kang, Ji‐Hye, et al. "Dietary capsaicin reduces obesity‐induced insulin resistance and hepatic steatosis in obese mice fed a high‐fat diet." Obesity 18.4 (2010): 780-787

Cancer
· Díaz-Laviada, I., & Rodríguez-Henche, N. (2014). The potential antitumor effects of capsaicin. Capsaicin as a Therapeutic Molecule, 181-208.
· Lin, Chia-Han, et al. "Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells." BMC complementary and alternative medicine 13.1 (2013): 1-9.
· Popescu GDA, Scheau C, Badarau IA, et al. The Effects of Capsaicin on Gastrointestinal Cancers. Molecules. 2020;26(1):94. Published 2020 Dec 28. doi:10.3390/molecules26010094

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