Ocrevus is touted as a highly effective therapy for MS, but long term continuous use increases the risk of infections. Do you really need to take it every 6 months? Can you take breaks to allow the immune system recover? Is it possible to do blood tests to predict when a relapse will occur? This video reviews a study from Amsterdam looking at extended interval dosing of Ocrevus, and we try to answer these questions.

Selected Sources:

Article I am discussing: Extended interval dosing of ocrelizumab modifies the repopulation of B cells without altering the clinical efficacy in multiple sclerosis: https://jneuroinflammation.biomedcent...
Ocrevus product label: https://www.accessdata.fda.gov/drugsa...
Ocrelizumab Extended Interval Dosing in Multiple Sclerosis in Times of COVID-19: https://pubmed.ncbi.nlm.nih.gov/34261...
Extended interval dosing of ocrelizumab reduces risk of developing hypogammaglobulinaemia: https://jnnp.bmj.com/content/93/9/e2....
Is It Time for Ocrelizumab Extended Interval Dosing in Relapsing Remitting MS? Evidence from An Italian Multicenter Experience During the COVID-19 Pandemic: https://pubmed.ncbi.nlm.nih.gov/36036...


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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.