Presented By: Siva Vanapalli, PhD

Speaker Biography: Dr. Siva Vanapalli is a Professor in Chemical Engineering and the Bryan Pearce Bagley Regents Chair at Texas Tech University. He holds a PhD degree in Chemical Engineering from the University of Michigan, MS degree in food science from Penn State and a B.Tech degree in food engineering from IIT Kharagpur. He has pursued research in the areas of microfluidics, complex fluids, food science, cancer, healthy aging and technology development, with more than 80 publications, 2500 citations and 25 invited lectures. He received the CAREER Award from the National Science Foundation and the Rising Star Award from the Cell & Molecular Bioengineering Group of Biomedical Engineering Society. Two spin-off companies NeoFluidics and NemaLife have been launched from IP generated out of his laboratory. He led two space-flight experiments with NASA and supported two other space-flight experiments for ESA - focusing on how microgravity affects nematode physiology and gene expression.

Webinar: Microfluidics Platforms for High Throughput In Vivo Screening

Webinar Abstract: Preclinical research and development are the cornerstone of modern drug discovery. A variety of biological systems including in vitro, 3D cultures, and organoids are essential tools, with ultimately lead candidates being tested in animal models. Microfluidics has played a significant role in advancing research and providing high content data in in vitro biological systems. In this talk, I will discuss our laboratory’s effort to apply microfluidic approaches to perform high throughput phenotypic screening in C. elegans – a nematode that offers human-relevant biology and is suitable to microfluidic automation. This in vivo model addresses the limitations of in vitro models, where tissue-level and multi-organ interactions are difficult to capture. Likewise, it alleviates the need for expensive and unsustainable testing in rodent models. Thus, C. elegans based phenotypic screening offers an attractive paradigm to re-think modern drug discovery.

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