Randomized double blind placebo-controlled trials are the gold standard, but things get complicated in nutrition….Subscribe to Nourishable at    / @nourishable  

Check out our whole nutrition study design series:    • Hierarchy of Evidence Series  
Hierarchy of Evidence Overview:    • How to Study Studies, Explained by a ...  
Cross-Sectional Studies:    • Cross-Sectional Studies are Snapshots...  
Case-Control Studies:    • Case-Control Studies Look Backwards i...  
Prospective Cohort Studies:    • What We Can Learn From Prospective Co...  
Meta-Analyses:    • Meta-Analysis, A Study of Studies | H...  

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00:00 Intro
00:37 Randomized Controlled Trial Definition
02:08 Randomized
03:02 Double-Blind
04:09 Placebo Controlled
05:01 Placebo Effect
06:03 Example RCT: High Fructose Corn Syrup Sweetened Beverages on Liver Fat and Insulin Sensitivity Study Design
07:38 Study Results
07:58 Dose-response Relationship
08:27 Interpreting randomized controlled trials in nutrition
10:21 Why placebo controls are tricky in nutrition
11:27 Applying results to real life
12:30 Randomized Controlled Trials in the Hierarchy of Evidence


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Hosting, Research, Writing & Post-Production by Lara Hyde, PhD    / @nourishable  

Actors: Patrice Nicole Doherty, Don Smith-Weiss

Music & Video Production by Robbie Hyde    / chedderc.  .

Opening Motion Graphics by Jay Purugganan https://www.c9studio.com/WP/

The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images and information, contained on or available through this video is for general information purposes only.

Script with in-text citations: https://bit.ly/NutritionRCTs

References
Sigala DM, Hieronimus B, Medici V, Lee V, Nunez MV, Bremer AA, et al. The Dose-Response Effects of Consuming High Fructose Corn Syrup-Sweetened Beverages on Hepatic Lipid Content and Insulin Sensitivity in Young Adults. Nutrients. 2022;14. https://pubmed.ncbi.nlm.nih.gov/35458...
Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O, et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014;514: 181–186.

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