Over 32 million people are infected with the Human Immunodeficiency virus each day. In rare cases, HIV has already been cured in cancer patients. But this might soon change. New promising HIV cures might be developed in the next years and finally stop HIV.

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HIV has been cured twice so far (Tim's case):    • Second Person Cured of HIV! HIV News ...  
New potential HIV vaccine:    • Is the new HIV Vaccine REALLY Effective?  

0:00-1:36 Intro
1:10-4:02 How HIV Infections Work
4:02-6:35 HIV Cures & Gene Editing
6:35- Attacking HIV by Latency Reversal
7:56-9:54 Immunotherapies in HIV Research

HIV, or human immunodeficiency virus, is a virus which causes the Acquired immunodeficiency syndrome, or AIDS. HIV infects CD4+ T cells and integrates its genetic information into the host cell. The infection of HIV is often not recognized for years, as HIV sequences remain inactive for a very long time. Once enough T cells are destroyed, however, AIDS breaks out. Symptoms of AIDS include recurring fever, weight loss, skin rashes and persistent white lesions on the tongue or mouth. Without intervention AIDS is fatal.
Today, we can treat HIV. HIV treatments, however, have side-effects and HIV can also become resistant. This is why we need a cure for HIV. Scientists are currently trying to find HIV cures. Using genetic engineering, CCR5 can be disrupted in immune cells making them HIV resistant. Another HIV cure could potentially be combined with latency reversal where we try to activate and destroy HIV particles. As a last HIV cure, scientists try to use broadly neutralizing antibodies which help the immune system to destroy HIV. These promising results might lead to an effective HIV cure one day.

0:00-1:10 Intro
1:10-3:20 How HIV Infections Work
3:20-6:09 Why HIV Vaccines are Challenging
6:09-9:20 HIV Vaccine 2021

For your Reading:
https://www.ncbi.nlm.nih.gov/pmc/arti...
https://www.ncbi.nlm.nih.gov/pmc/arti...
https://www.nature.com/articles/nbt.1663
https://www.ncbi.nlm.nih.gov/pmc/arti...
https://www.hindawi.com/journals/art/...
https://www.nature.com/articles/s4146...

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About Clemens Steinek:
CLEMENS STEINEK is a PhD student/youtuber (LifeLabLearner) who is currently conducting stem cell research in Germany.