I believe that aging is our greatest humanitarian challenge, and that science can help us solve it. Find out more about my book, Ageless: The new science of getting older without getting old, at https://ageless.link/

Where to buy

US
Amazon: https://ageless.link/amazon-us
Apple Books: https://ageless.link/apple-books-us
Barnes & Noble: https://ageless.link/barnesandnoble
Books-A-Million: https://ageless.link/booksamillion
Bookshop.org https://ageless.link/bookshop.org
Penguin Random House https://ageless.link/prh
Audiobook on Audible: https://ageless.link/audible-us

UK
Support independent bookshops by ordering from Hive: https://ageless.link/hive
Waterstones: https://ageless.link/waterstones
Amazon: https://ageless.link/amazon-uk
Audiobook on Audible: https://ageless.link/audible-uk

Australia
Amazon: https://ageless.link/amazon-au
Audiobook on Audible: https://ageless.link/audible-au

Other countries
Ageless is also available in other countries around the world—just search for Ageless wherever you get your books, and you should be able to find a copy in English. It’s also in the process of being translated into (so far) ten different languages. I’ll add links here when these become available!

Some links are affiliate links and I will receive a small payment if you choose to purchase through them. Thanks!


Video chapters

00:00 Introduction
00:57 Why aging is our largest humanitarian challenge
05:24 How science could help
06:07 The hallmarks of aging
06:22 Senescent cells
08:55 Preventative treatments for aging
11:04 Where to get Ageless


Sources

Here are some of the sources I used when researching this video:

Calculation of number of deaths caused by aging based on Human Mortality Database data. You can find a report explaining the calculations, and the code behind it, on GitHub: https://github.com/ajsteele/ageless

Calculations of disease risk with age based on World Health Organization Global Burden of Disease (WHO GBD) statistics. Calculations also available at https://github.com/ajsteele/ageless

Coronavirus mortality with age (technically the age-specific infection fatality rate) was extracted from Figure 2(A) in this paper: O’Driscoll, et al., Nature (2020). https://doi.org/10.1038/s41586-020-29...

The hallmarks of aging I list are the ones I used in Ageless. They’re based on a paper called the Hallmarks of Aging, published in 2013, which enumerated nine hallmarks. I added two and combined two together, giving one extra hallmark overall. López-Otı́n et al., Cell 153, 1194–1217 (2013). https://doi.org/10.1016/j.cell.2013.0...

The 2011 paper in which scientists removed senescent cells with a ‘suicide gene’: Baker et al., Nature 479, 232–36 (2011) https://doi.org/10.1038/nature10600

The 2015 paper describing the first ‘senolytic’ drug combination, dasatinib plus quercetin: Zhu et al., Aging Cell 14, 644–58 (2015) https://doi.org/10.1111/acel.12344


Thanks

Thanks to Tran Nguyen for her help with this video!    / @drmedtran     / drmedtran