Guillain barre | Molecular mimicry
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 Published On Nov 20, 2023

Guillain barre is the main cause of short-term muscle weakness or the short-term inability to move your muscles. It is primarily caused by the bacteria Campylobacter jenjuni which is found in undercooked, infected chicken. One to three weeks after your immune system fights off the infection, the immune cells begin to target the nerves. This is due to molecular mimicry. The bacteria has a protein that looks almost exactly like the coating of your nerves. Therefore, the B cells, T cells, and macrophages begin to destroy the myelin coating around nerves and even destroy nerves themselves. Nerve destruction leads to the inability to move. Removing the antibodies that the B cells make seem to improve Guillain barre in 80% of people affected. The antibodies are removed through plasmapheresis (similar to dialysis). .

Sources:

https://www.ncbi.nlm.nih.gov/pmc/arti...

https://www.cdc.gov/campylobacter/gui....

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