Many people are wondering what is Antibody Dependent Enhancement or ADE. Antibody Dependent Enhancement (ADE) is a second key for a virus to enter your immune cells. Viruses have spike proteins that allow it to enter one or two types of cells like lung cells or neurons. That is the first key. If antibodies bind to a virus in a non-neutralizing way, the virus can enter immune cells called macrophages. This is the second key. Having an antibody bind in a non-helpful, non-neutralizing way allows the virus to enter macrophages and gives the virus an advantage. ADE happens naturally during dengue virus infections. It has also happened during RSV vaccine trials. However, there is no evidence that ADE is happening now with COVID-19.