Dr. Peter Attia on Mastering Longevity – Insights on Cancer Prevention, Heart Disease, and Aging
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 Published On Premiered Dec 27, 2023

@PeterAttiaMD is a highly respected expert in preventive medicine with a special focus on the applied science of longevity. His deep engagement with the topic of longevity is the cornerstone of his NY Times bestselling book, 'Outlive: The Science and Art of Longevity'. Dr. Attia also extends his expertise into his clinical practice Early Medical and shares his knowledge through his popular podcast many of you are already aware of, 'The Drive.'

EPISODE LINKS:
Show notes and transcript: https://www.foundmyfitness.com/episod...
Dr. Peter Attia on Twitter:   / peterattiamd  
Dr. Peter Attia on Instagram:   / peterattiamd  
Dr. Peter Attia's Website: https://peterattiamd.com
The Drive Podcast: https://podcasts.apple.com/us/podcast...
"Outlive: The Art and Science of Longevity" Book: https://www.amazon.com/Outlive-Longev...

CHAPTERS:
(00:00:00) In this episode
(00:04:29) Defining cardiovascular disease
(00:06:36) Coronary plaque and fatality risk
(00:08:02) What is cholesterol?
(00:10:27) How ApoB predicts heart disease
(00:18:27) Factors elevating ApoB
(00:22:17) ApoB reference range explained
(00:24:16) Does high ApoB cause cardiovascular disease
(00:33:54) ApoB thresholds for ASCVD prevention
(00:37:20) Dietary factors raising ApoB
(00:36:26) Genetics of ApoB and LDL
(00:50:17) Does low LDL increase cancer?
(00:53:12) Cholesterol-lowering drugs
(00:56:52) Statins, uses, and side effects
(01:00:05) Are statins toxic to mitochondria?
(01:06:49) Ubiquinol for statin-induced muscle soreness
(01:08:02) How to train in zone 2
(01:14:02) Statins and neurodegenerative disease risk
(01:18:47) Cholesterol synthesis in the brain (desmosterol role)
(01:22:51) Statin alternatives – pros and cons
(01:24:23) Ezetimibe
(01:27:54) Bempedoic acid
(01:33:42) Berberine for CVD Risk Reduction?
(01:36:29) Muscle as a glucose sink
(01:42:51) Chronic glucose toxicity and vascular impact
(01:48:31) Hemoglobin A1C Levels and Mortality Data
(01:52:28) 80/20 Zone 2/VO2 Max Training Protocol
(01:59:05) Insights from VO2 max testing data
(02:09:10) How obesity increases cancer risk
(02:11:56) Cancer screening benefits and risks
(02:17:40) Dr. Attia's recommended cancer screening age
(02:25:47) Liquid biopsies for detecting cancer
(02:31:41) CT scans, mammograms and radiation concerns
(02:37:25) Menopause – hormonal shifts and health effects
(02:42:06) Hormone replacement therapy (HRT)
(02:55:50) Perimenopause diagnosis with hormone levels
(02:58:57) HRT's impact on dementia, cancer, and heart disease risk
(03:01:42) Estrogen's role in bone density
(03:04:35) Vitamin D
(03:13:17) Testosterone replacement for women's sexual function
(03:15:40) HRT safety 10 years post-menopause
(03:19:58) Treating low testosterone in men
(03:26:46) TRT side effects and risks
(03:29:26) Ways to reduce blood pressure
(03:36:26) How to measure blood pressure
(03:42:23) Peter's longevity optimization routines

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