Why do we age? It’s a simple question, without, of yet, a simple answer.

Now there are many theories of aging - its DNA damage, its free radicals, it cross-linking, its nutrient sensing, its the endocrines, its programmed, its epigenetics and loss of information, its immune decline, it’s the mitochondria, it’s good old wear and tear, it’s p53, telomere shortening, it’s antagonistic pleiotropy, its senescence accumulation... well.

Three things i have found myself doing a lot these past few weeks include reading very rare and old biology books, thinking about how different scientists are defining aging and thinking of silly things to write in a YouTube script. In this video, we’ll stick with the first two, the latter being a given. Now there are many theories of why we age, i have an entire playlist of videos talking about many of them, but i felt like we needed an update in light of some recent not-so-light reading i’ve been doing. So, in this video, we’ll consider what is the current major thoughts regarding why we age and consider whether aging is programmed or if aging is loss of entropy . So, we’ll cover a lot, so “brace yourselves”.

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TIMESTAMPS:
Intro - 00:00
Theories of aging - 01:00
Why we age - 05:00
What's the solution - 13:20

References:
de Magalhães, J.P. Ageing as a software design flaw. Genome Biol 24, 51 (2023). https://doi.org/10.1186/s13059-023-02...
Poljsak B, Dahmane R, Adamič M, et al. THE (A)SYMMETRY OF THE MALE GRAYING BEARD HAIRS AS AN INDICATION OF THE PROGRAMMED AGING PROCESS. Acta Clin Croat. 2020;59(4):650-660. doi:10.20471/acc.2020.59.04.11
Bujarrabal-Dueso, A., Sendtner, G., Meyer, D.H. et al. The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities. Nat Struct Mol Biol 30, 475–488 (2023). https://doi.org/10.1038/s41594-023-00...
Lakatta EG. The reality of aging viewed from the arterial wall. Artery Res. 2013 Jun 1;7(2):73-80. doi: 10.1016/j.artres.2013.01.003. PMID: 23667404; PMCID: PMC3646655.

Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.

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