The Illinois Biological Foundry for Advanced Biomanufacturing (iBioFAB)

 Published On Dec 7, 2023

This video is designed to show off just some of the capabilities of the iBioFAB, housed inside the Carl R. Woese Institute for Genomic Biology on the University of Illinois campus. The iBioFAB aims to accelerate the biological engineering process by integrating artificial intelligence/machine learning with automation. This synthetic biology foundry features a 6-degree-freedom articulated robotic arm that travels along a 5-meter-long track to transfer microplates among more than 20 instruments installed on the platform.

The system houses three liquid handling devices: the nanoliter-scale Labcyte Echo 550 acoustic liquid handler in addition to the pipet-based Tecan Freedom EVO 200 and Tecan Fluent 1080 systems.
At maximum capacity, this biofoundry can house over 500 96-well plates within its four Thermo-Fisher Cytomat automated incubators. Coupled with an integrated laboratory information management system (LIMS) and scheduling software, the iBioFAB can generate thousands of output samples each day using custom-designed workflows for plasmid assembly, microbial transformations, and more.

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