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How do you stop pepper burn if you can’t drink milk? This week Sam and George suffer for science. #peppers #burn #spicyfood

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Credits:
Executive Producers:
George Zaidan
Hilary Hudson

Producers:
Andrew Sobey
Elaine Seward

Writer/Host:
Samantha Jones, PhD

Scientific consultants:
John Hayes, PhD
Alissa Nolden, PhD
Michelle Boucher, PhD
Lelia Duman, PhD

Sources:

Capsaicin https://www.ncbi.nlm.nih.gov/books/NB...

The chemistry of a chili
https://www.compoundchem.com/2014/01/...

Understand spiciness: mechanism of TRPV1 channel activation by capsaicin
https://www.ncbi.nlm.nih.gov/pmc/arti...

Capsaicin, Nociception and Pain
https://www.ncbi.nlm.nih.gov/pubmed/2...

Capsaicin: Risks and Benefits
https://www.uspharmacist.com/article/...

The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation.
https://www.ncbi.nlm.nih.gov/pubmed/1...

Integrative Approaches to Pain Management
https://www.sciencedirect.com/science...

The cool science of hot peppers https://www.sciencenewsforstudents.or...

Unraveling the mystery of capsaicin https://www.ncbi.nlm.nih.gov/pmc/arti...

Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other
Pre-Clinical and Clinical Uses https://www.ncbi.nlm.nih.gov/pmc/arti...

Capsaicin may have important potential for promoting vascular and metabolic health https://www.ncbi.nlm.nih.gov/pmc/arti...

Capsaicin chemical structure https://pubchem.ncbi.nlm.nih.gov/comp...
Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases
https://www.ncbi.nlm.nih.gov/pmc/arti...

Capsaicin: An Uncommon Exposure and Unusual Treatment
https://www.ncbi.nlm.nih.gov/pmc/arti...

Antimicrobial and Anti-Virulence Activity of Capsaicin Against Erythromycin-Resistant, Cell-Invasive Group A Streptococci
https://www.ncbi.nlm.nih.gov/pmc/arti...
Perceptual and Affective Responses to Sampled Capsaicin Differ by Reported Intake
https://www.ncbi.nlm.nih.gov/pmc/arti...

Personality factors predict spicy food liking and intake
https://www.ncbi.nlm.nih.gov/pmc/arti...

Capsaicin Improves Glucose Tolerance and Insulin Sensitivity Through Modulation of the Gut Microbiota-Bile Acid-FXR Axis in Type 2 Diabetic db/db Mice. https://www.ncbi.nlm.nih.gov/pubmed/3...

Learning to Like Spicier Food
https://www.theatlantic.com/health/ar...

Why some people can tolerate the world’s hottest pepper
https://scienceline.org/2016/12/why-s...

Advice on building tolerance (from a non-expert) https://www.pepperscale.com/spicy-foo...

Are People Born With A Tolerance For Spicy Food?
https://www.popsci.com/science/articl...

Serious Eats on how to build your spicy foods tolerance https://www.seriouseats.com/2010/08/h...

A randomized, double-blind, positive-controlled, 3-way cross-over human experimental pain study of a TRPV1 antagonist (V116517) in healthy volunteers and comparison with preclinical profile.
https://www.ncbi.nlm.nih.gov/pubmed/2...

Chili peppers for weight loss
https://www.tandfonline.com/doi/abs/1...

Anti-obesity Effect of Capsaicin in Mice Fed with High-Fat Diet Is Associated with an Increase in Population of the Gut Bacterium Akkermansia muciniphila
https://www.frontiersin.org/articles/...

Milk for chili peppers (Kool Aid?) https://www.sciencedaily.com/releases...

Do Genetics Shape Your Spicy-Food Threshold?
https://firstwefeast.com/features/201...

Ask the doctor: How does hot pepper cream work to relieve pain?
https://www.health.harvard.edu/pain/h...

Why do some like it hot? Genetic and environmental contributions to the pleasantness of oral pungency
https://www.sciencedirect.com/science...



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